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In this issue of Clinical Cancer Research, evidence is provided on how to avoid cardiotoxicity when targeting hERG K + channel for cancer therapy. hERG regulates different aspects of neoplastic progression. Although its blockade has effective anticancer effects in experimental models, it may lead to fatal arrhythmias in humans. Clin Cancer Res; 23(1); 3-5. ©2016 AACRSee related article by Pointer et al., p. 73.

hERG Channels: From Antitargets to Novel Targets for Cancer Therapy