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Lymph node metastasis is the most important predictor of prognosis in esophageal squamous cell carcinoma (ESCC). Recently, KiSS-1 was cloned as a human metastasis suppressor gene, and an orphan G-protein-coupled receptor (hOT7T175) was identified as the endogenous receptor of the KiSS-1 product. However, the clinical importance of KiSS-1 and hOT7T175 gene expression in ESCC remains unclear.

clinical cancer research

Clinical Significance of the Loss of KiSS-1 and Orphan G-Protein–Coupled Receptor ( hOT7T175 ) Gene Expression in Esophageal Squamous Cell Carcinoma