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To assess the prevalence of phosphoinositide 3-kinase (PI3K) pathway alterations in pure high-grade ductal carcinoma in situ (DCIS) and DCIS associated with invasive breast cancer (IBC), and to determine whether DCIS and adjacent IBCs harbor distinct PI3K pathway aberrations.

PI3K Pathway Activation in High-Grade Ductal CarcinomaIn Situ—Implications for Progression to Invasive Breast Carcinoma