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The applicability of radioimmunotherapy with organism-specific monoclonal antibodies to treatment of infectious disease in experimental models has been recently shown for fungal, bacterial, and viral infections. To identify the best delivery vehicle for radioimmunotherapy of human pathogenic fungus Cryptococcus neoformans (CN), we have done comparative evaluation of capsular polysaccharide-specific antibodies with IgG1 and IgM isotypes and F(ab')2 and Fab fragments.

clinical cancer research

Comparative Evaluation of Capsular Polysaccharide-Specific IgM and IgG Antibodies and F(ab′)2 and Fab Fragments as Delivery Vehicles for Radioimmunotherapy of Fungal Infection