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Circulating inflammation proteins may be important mediators or markers of carcinogenic mechanisms. There have been few studies with limited numbers of analytes in patients with upper gastrointestinal (GI) tract tumors. We therefore evaluated risk associations of gastric and esophageal cancers with prediagnostic levels of a wide range of these molecules.

cancer epidemiology, biomarkers and prevention

Circulating Inflammation Markers and Risk of Gastric and Esophageal Cancers: A Case–Cohort Study Within the Japan Public Health Center–Based Prospective Study