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Radiotherapy decreases cancer mortality, but is associated with an increased incidence of second primary cancers, including osteosarcomas, especially after exposure in childhood. It remains uncertain whether radiation is related to other histologic types of bone sarcomas such as chondrosarcomas that are more common in adulthood.

Patterns of Bone Sarcomas as a Second Malignancy in Relation to Radiotherapy in Adulthood and Histologic Type