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Disparities in cancer defined by race, age, or gender are well established. However, demographic metrics are surrogates for the complex contributions of genotypes, exposures, health care, socioeconomic and sociocultural environment, and many other factors. Macroenvironmental factors represent novel surrogates for exposures, lifestyle, and other factors that are difficult to measure but might influence cancer outcomes.

cancer epidemiology, biomarkers and prevention

Context-Dependent Effects of Genome-Wide Association Study Genotypes and Macroenvironment on Time to Biochemical (Prostate Specific Antigen) Failure after Prostatectomy