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Mammographic density is a strong risk factor for breast cancer, usually measured by an area-based threshold method that dichotomizes the breast area on a mammogram into dense and nondense regions. Volumetric methods of breast density measurement, such as the fully automated standard mammogram form (SMF) method that estimates the volume of dense and total breast tissue, may provide a more accurate density measurement and improve risk prediction.

cancer epidemiology, biomarkers and prevention

Screen-Film Mammographic Density and Breast Cancer Risk: A Comparison of the Volumetric Standard Mammogram Form and the Interactive Threshold Measurement Methods