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Liver cirrhosis and its complications, including esophageal and gastric variceal bleeding, hepatic encephalopathy, and ascites, can cause serious harm to human health. Therefore, treatment of l iver f ibrosis is key to the prevention and treatment of liver cirrhosis. n ■背景资料 尽管预防及治疗 肝硬化的药物不 断 被 研 制 问 世 , 并且诊疗手段及 检查仪器越来越 先进 , 但仍然缺 乏一种安全、高 效、可靠的抗凝 治疗方案来预防 及治疗肝纤维化. 因此 , 本文对凝 血功能和抗凝治 疗对肝脏纤维化 影响的研究进展 作一综述 , 希望 找到防治肝纤维 化的有效途径. order to treat liver fibrosis to reduce human suffering, medical experts and scholars have performed many clinical and animal studies to find safe, efficient and reliable drugs to slow the progression of hepatic fibrosis and even reverse the liver function. This review introduces the definition of liver fibrosis in China and other countries, discusses the effect of coagulation on the process of liver fibrosis and various anticoagulation therapies for liver fibrosis, and summarizes the advantages, disadvantages, and side effects of different anticoagulants in the prevention and treatment of liver fibrosis. © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

Impact of coagulation function and anticoagulation therapy on liver fibrosis