English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

AIM: To investigate the effect of insulin-like growth factor-I (ICF-I) on hepatic fibrosis in rats and its possible mechanism. METHODS: Fifty Sprague-Dawley rats were randomly divided into 4 groups: normal group (n = 10), olive oil group (n = 10), model group (n = 15) and ICF-I group (n = 15). The hepatic fibrosis model was induced by 40% CCl4. The rats with hepatic fibrosis were injected with IGF-1 subcutaneously four weeks later (2 μg/kg, every other day for 2 weeks). The survival rate, fibrotic degree and body weight of the rats were inspected. The histopathological changes of collagenous fiber were examined under optical microscope. The content of α-smooth muscle actin (α-SMA) in the liver tissue were detected by Western-blotting. RESULTS: In comparison with those in model group, the weights of the rats in ICF-I group were significantly higher (252.1±24.1 g vs 301.5±32.4 g, P <0.05); the survival rate was higher and the fibrotic degrees were remarkably lower; the content of collagen and α-SMA in the liver tissue were significantly reduced. CONCLUSION: IGF-1 can protect rats against hepatic fibrosis, which may be related to its role in improving hepatic function and inhibiting HSC activation.

Effect of insulin-like growth factor-I on hepatic fibrosis in rats