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The possibilities of jow injection analysis for the on-line monitoring of dissolution tests are illustrated by using a very straightforward manifold to monitor tablets of ascorbic acid dissolving at different rates. The dissolution kinetics can be monitored at an adequate samplingfrequency as the method allows up to 90 samples to be processed per hour. Flow Injection Analysis (FIA) has proved to be a useful tool for on-line process monitoring 1,2] and pharmaceutical analysis [3-5]. Both applications are of great importance in the monitoring of dissolution tests of solid dosage forms. Dissolution tests on pharmaceuticals are commonplace quality control procedures and facilitate meeting the legal requirements for compendial drugs, and for oral-dosage forms which are not yet listed in compendia. Conventional approaches to the monitoring ofdissolution processes occurring simultaneously in the ’controller’,

Potential of flow injection analysis for dissolution tests: application to on-line monitoring of tablets with different dissolution rates