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’Health’ is a concept that is difficult to define. A well-known definition is given by the World Health Organization (WHO): health is a state of complete physical, mental and social well-being, and not merely the absence of disease or infirmity. Some authors, for example Grfisbeck [1], have criticized this definition as unrealistic and have proposed others that stress the absence of undesirable affections, the so-called privative definitions. A more complete discussion of the notion ’health’ is beyond the scope of this paper.

Critical discussion on a method for derivation of reference limits in clinical chemistry from a patient population