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Using an ELISA technique, concentrations of gamma-interferon and interleukin-2 were assayed in the supernatants of colonic intraepithelial lymphocytes cultured with or without phytohaemagglutinin (PHA). IntraepitheHal lymphocytes produced low concentrations of gamma-interferon and interleukin-2 when stimulated with PHA, but significantly more than when unstimulated (p &lt; 0.05). There was no difference in production of these cytokines by IEL from control or inflammatory bowel disease.

Cytokine Production by Human Colonic Intraepithelial Lymphocytes in Controls and Ulcerative Colitis