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PPAR γ  plays a central role in the formation of fat. Regulation of PPAR γ  activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms. In addition, the interplay of PPAR γ  with other nuclear hormone receptors has implications for the balance between adipogenesis and osteogenesis in mesenchymal stem cells of the bone marrow stroma. This review will explore a range of factors influencing PPAR γ  activity and how these interactions may affect osteogenesis.

Fine-Tuning Reception in the Bone: PPARγand Company