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<p>This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of <mml:math>   <mml:mrow>    <mml:msub><mml:mrow><mml:mtext>CCl</mml:mtext></mml:mrow><mml:mn>4</mml:mn>    </mml:msub>   </mml:mrow> </mml:math>, and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragastric administration for 8 weeks. Liver histopathology and immunohistochemistry were significantly improved and the expressions of ICAM-1, VCAM-1, E-selectin, and TNF-<mml:math>   <mml:mi>&#x03B1;</mml:mi> </mml:math> mRNA and protein were decreased significantly in rats treated with a high dose of thalidomide. Close positive correlation was observed in the expression of the TNF-<mml:math>   <mml:mi>&#x03B1;</mml:mi> </mml:math> mRNA and that of ICAM-1, VCAM-1, and E-selectin mRNA, respectively. These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-<mml:math>   <mml:mi>&#x03B1;</mml:mi> </mml:math> signaling pathway to inhibit liver fibrosis.</p

Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis