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This study investigated the heme oxygenase-1 (HO-1) and theendotoxin-induced uveitis (EIU) in diabetic streptozotocin(STZ)-hyperglycemic rats. STZ-hyperglycemic rats had impairedlevels of the enzyme HO-1 within the ciliary bodies ifcompared with the nondiabetic rats. STZ-hyperglycemic rats alsopredisposed the eye to produce high levels of both the cytokinesIL-1β and CXCL8. Subsequent EIU further and significantly(P<.01) increased the cytokines production, an effect partlyprevented by hemin treatment. Most importantly, hemin, an inducerof heme oxygenase expression and activity, recovered the hugenumber of infiltrated polymorphonuclear leukocytes PMN within theciliary bodies associated with STZ-hyperglycemic state and EIUdamage. Impairment of the stress-sensitive enzyme HO-1 inSTZ-hyperglycemic rats increases and prolongs the inflammatoryresponse to EIU

mediators of inflammation

Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1