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The antitumour activities of four triorganophosphinegold(I) thiolates, R(2)PAu(S'R) [R = Ph, Cy, Et; SR'H = 6-mercaptopurine and R Et; SR'H = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy(3)PAu(6-MP)] complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy &gt; Ph &gt; Et. Sub-panel selectivity against the Leukemia cell lines was found for each of [Cy(3) PAu(6-MP)] and [Et(3)PAu(6-TG)].

metal-based drugs

A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>R</mml:mtext><mml:mtext>3</mml:mtext></mml:msub><mml:mtext>PAu</mml:mtext></mml:math>(S<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mtext>R</mml:mtext><mml:mo>′</mml:mo></mml:msup></mml:math>), R = Ph, Cy, E<scp>t</scp>; S<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mtext>R</mml:mtext><…

A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R3PAu(SR′), R = Ph, Cy, Et; SR<…