Open AccessPotential Pathophysiological Mechanisms Underlying Multiple Organ Dysfunction in Cytokine Release Syndrome
Author(s) -
Peixian Chen,
Yan Tang,
Weixin He,
Ruixuan Yang,
Zhien Lan,
Ruirong Chen,
Peidong Zhang
Publication year - 2022
Publication title -
mediators of inflammation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.37
H-Index - 97
eISSN - 1466-1861
pISSN - 0962-9351
DOI - 10.1155/2022/7137900
Subject(s) - mechanism (biology) , pathophysiology , cytokine , medicine , organ dysfunction , disease , multiple organ dysfunction syndrome , immunology , immune dysfunction , immune system , bioinformatics , cytokine release syndrome , intensive care medicine , covid-19 , biology , pathology , infectious disease (medical specialty) , sepsis , philosophy , epistemology
In recent decades, many serious respiratory infections have broken out all over the world, including SARS-CoV, MERS, and COVID-19. They are characterized by strong infectivity, rapid disease progression, high mortality, and poor prognosis. Excessive immune system activation results in cytokine hypersecretion, which is an important reason for the aggravation of symptoms, and can spread throughout the body leading to systemic multiple organ dysfunction, namely, cytokine release syndrome (CRS). Although many diseases related to CRS have been identified, the mechanism of CRS is rarely mentioned clearly. This review is intended to clarify the pathogenetic mechanism of CRS in the deterioration of related diseases, describe the important signaling pathways and clinical pathophysiological characteristics of CRS, and provide ideas for further research and development of specific drugs for corresponding targets to treat CRS.
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