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A novel, accurate, precise, inexpensive, and sensitive spectrophotometric approach is established to assay levodopa (LD) in both bulk drug and its pharmaceutical formulations. The method depends on the reaction of the ternary complex of a mixed-ligand type among LD, nickel(II) (Ni(II)), and 2,3-diaminopyridine (DAP) to form a stable complex of Ni-LD-DAP which is not extractable. The complex showed maximum absorption at 478 nm, with the apparent molar absorptivity of 4.93 × 103 L·mol−1·cm−1 and Sandell’s sensitivity of 0.04 μg·cm−2. Beer’s law is obeyed within the concentration range of 2–58 μg·mL-1, and the regression line equation is as follows: Y = 0.0251X + 0.0045 (R2 = 0.9990; n = 5). The detection limit and quantitation limit are found to be 0.1388 μg·mL−1 and 0.4207 μg·mL−1, respectively. The present study achieved reasonable accuracy (average recovery of 100.17%) and good precision (RSD did not exceed 1.71%). The developed method has been validated according to the current ICH guidelines (2013). The results of pure LD and pharmaceutical preparations using the recommended spectrophotometry are promising.

Ternary Complexation Process for New Spectrophotometric Assay of Levodopa using Ni(II) and 2,3-Diaminopyridine