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Objective. To investigate the combined impact of aerobic exercise and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on brain cells longevity in spite of sex hormones deficiency in obese postmenopausal women. Design. A parallel randomized clinical trial. Subjects/Patients. Sixty-eight eligible postmenopausal women were randomly assigned to one of two groups, one experimental and one control. The participants’ age ranged from 60 to 75 years, and their body mass index ranged from 30 to 39.9 kg/m2. Methods. An experimental group whose members followed moderate-intensity treadmill exercise three times/week for three months with MIND diet and a control group whose members followed the MIND diet only. In addition to serum sex hormones, pre- and post-12-week assessments were performed to measure serum sex hormones as well as cognitive and functional levels. Results. The experimental group showed after intervention highly significant changes ( p &lt; 0.01 ) in sex hormones, cognitive functions, and functional levels compared with the control group ( p &lt; 0.05 ). In addition, no correlation was found between the measured variables in both groups after intervention ( p &gt; 0.05 ). Conclusion. Aerobic exercise combined with the MIND diet improves cognitive and functional levels and substitutes sex hormones deficiency in postmenopausal women, which affects the longevity of brain health.

oxidative medicine and cellular longevity

Aerobic Exercise with Mediterranean-DASH Intervention for Neurodegenerative Delay Diet Promotes Brain Cells’ Longevity despite Sex Hormone Deficiency in Postmenopausal Women: A Randomized Controlled Trial