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The deficiency of vitamin D has been reported to be relevant to cancer risk.  DHCR7  and  CYP2R1  are crucial components of vitamin D-metabolizing enzymes. Thus, accumulating researchers are concerned with the correlation between polymorphisms of  DHCR7  and  CYP2R1  genes and cancer susceptibility. Nevertheless, the conclusions of literatures are inconsistent. We conducted an integrated review for the correlation of  DHCR7  and  CYP2R1  SNPs with cancer susceptibility. In the meanwhile, a meta-analysis was performed using accessible data to clarify the association between  DHCR7  and  CYP2R1  SNPs and overall cancer risk. Literatures which meet the rigid inclusion and exclusion criteria were involved. The association of each SNP with cancer risk was calculated by odds ratios (ORs). 12 case-control designed studies covering 23780 cases and 27307 controls were ultimately evolved in the present meta-analysis of five SNPs ( DHCR7  rs12785878 and rs1790349 SNP;  CYP2R1  rs10741657, rs12794714, and rs2060793 SNP). We found that  DHCR7  rs12785878 SNP was significantly related to cancer risk in the whole population, Caucasian subgroup, and hospital-based (HB) subgroup.  DHCR7  rs1790349 SNP was analyzed to increase cancer risk in Caucasians. Moreover,  CYP2R1  rs12794714-A allele had correlation with a lower risk of colorectal cancer. Our findings indicated that rs12785878, rs1790349, and rs12794714 SNPs might potentially be biomarkers for cancer susceptibility.

Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis