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This work aimed to explore the effects of image mosaic algorithm- (IMA-) based low-dose X-rays on deoxyribonucleic acid (DNA) damage of peripheral blood lymphocytes in cardiovascular patients. 84 patients with interventional cardiovascular surgeries were selected as the research objects and divided into coronary intervention surgery (A) group, coronary angiography (B) group, radiofrequency ablation (C) group, and permanent cardiac pacemaker implantation (D) group. They were treated with IMA-based low-dose X-rays, DNA damage indicators of lymphocytes were detected, and the relationship was analyzed between those indicators and radiation dose. Results showed that the cumulative dose (CD) and dose area product (DAP) of group A were the lowest, and those of group D were obviously higher than those of the other three groups ( P &lt; 0.01 ). Besides, the results also showed that the values of CD and DAP of patients from group A and group D were 0.38 ± 0.08 (Gy) and 0.38 ± 0.08 (Gy/cm2) and 1.37 ± 0.21 (Gy) and 1.37 ± 0.21(Gy/cm2), respectively. The comet tail DNA content (TDNA) and tail moment (TM) of each group after surgery increased dramatically compared with before surgery ( P &lt; 0.01 ), and the TDNA and TM of group D were greatly higher than those of the other three groups ( P &lt; 0.01 ). Therefore, TDNA and TM were markedly positively correlated with DAP and CD ( P &lt; 0.01 ). IMA-based X-ray radiotherapy caused reliable DNA damage to peripheral blood lymphocytes of cardiovascular patients, and the greater the radiation dose, the more serious the DNA damage.

Image Mosaic Algorithm-Based Analysis of Effects of Low-Dose X-Rays on Blood Immune Cells