English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objective   To observe the inhibitory effect of solanine on regulatory T cells (Treg) in transplanted hepatoma mice and to study the mechanism of solanine inhibiting tumor growth.Methods   The levels of Treg cells and IL-2, IL-10, and TGF β  in the blood of patients with liver cancer were detected by flow cytometry and ELISA, respectively. A mouse hepatocellular carcinoma (HCC) graft model was established and randomly divided into four groups: control group, solanine group, TGF β  inhibitor group (SB-431542), and solanine  + TGF β  inhibitor combined group. Tumor volume of each group was recorded, tumor inhibition rate was calculated, and tumor metastasis was counted. The proportion of CD4 + CD25 + Foxp3 +  Treg in transplanted tumor tissues was detected by flow cytometry. The expression levels of Foxp3 and TGF β  in transplanted tumor tissues were detected by quantitative fluorescence PCR.Results   Compared with healthy people, Treg cells and IL-2, IL-10, and TGF β  contents in peripheral blood of liver cancer patients were increased. The results of the transplanted tumor model in mice showed that the tumor volume of the transplanted mice in the solanine group and the TGF β  inhibitor mice was reduced compared with the control group. The combined group had the smallest tumor volume. The proportion of CD4 + CD25 + Foxp3 +  Treg in the transplanted tumor tissues of mice in the solanine treatment group was significantly lower than that in the control group. The expressions of Foxp3 and TGF β  in the transplanted tumor tissues of mice in the solanine group were significantly lower than those in the control group.Conclusion   Solanine may enhance the antitumor immune response by downregulating the proportion of CD4 + CD25 +  Treg and the expression of Foxp3 and TGF β  in tumor tissues.

Solanine Inhibits Immune Escape Mediated by Hepatoma Treg Cells via the TGFβ/Smad Signaling Pathway