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Background    Hagenia abyssinica  (Bruce) J.F. Gmel (Rosaceae) is distributed in the highlands of Ethiopia. The flowers of  Hagenia abyssinica  (Bruce) J.F. Gmel are used traditionally to treat wound. However, there was no scientific report on wound healing activity of  Hagenia abyssinica  (Bruce) J.F. Gmel. Thus, this study was initiated to investigate the wound healing and anti-inflammatory activities of 80% methanol crude extract of flowers of  Hagenia abyssinica  in mice.Objective   The objective of this study was to evaluate the wound healing and anti-inflammatory activity of 80% methanol crude flower extract of  Hagenia abyssinica  in mice.Methods   Air-dried flowers of  Hagenia abyssinica  were grounded and macerated three times successively by 80% methanol. The dried extract was fractionated with chloroform, ethyl acetate, and water. Phytochemical screening tests were performed according to established procedures. The crude extract and solvent fractions were formulated as ointments. Wound healing activity of the crude extract was evaluated using excision and incision wound models, and the wound healing activities of solvent fractions were evaluated by using the excision wound model. The anti-inflammatory activity of the 80% methanol extract of  Hagenia abyssinica  was evaluated using carrageenan-induced hind paw edema model in mice.Result   The 2000 mg/kg test dose of the 10% (w/w) crude extract ointment was safe in rats. Both the 5% (w/w) and 10% (w/w) crude extract ointment-treated groups showed significant wound contraction starting from the day 4 th . Both 5% (w/w) and 10% (w/w) crude extract ointments showed significant ( P  < 0.001) increment of tensile strength compared to the negative control. The 10% (w/w) aqueous and ethyl acetate fraction ointment revealed high ( P  < 0.001) percentage of wound contraction. The 100 mg/kg, 200 mg/kg, and 400 mg/kg oral administration of the crude extract had significant inhibition of the paw edema in mice of carrageenan-induced inflammation.Conclusion   The results of this study evidenced that both 5% w/w and 10% w/w 80% methanol extract ointment of the flowers of  Hagenia abyssinica  have wound healing and anti-inflammatory effects.

evidence-based complementary and alternative medicine

In Vivo Evaluation of Wound Healing and Anti-Inflammatory Activity of 80% Methanol Crude Flower Extract of <i>Hagenia abyssinica</i> (Bruce) J.F. Gmel in Mice

In Vivo Evaluation of Wound Healing and Anti-Inflammatory Activity of 80% Methanol Crude Flower Extract of Hagenia abyssinica (Bruce) J.F. Gmel in Mice