English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background   The progression of  Helicobacter pylori -associated gastritis towards atrophic gastritis is modulated by host-related and environmental factors. Studies that explore the possible involvement of host-related versus environmental factors in the development of gastritis phenotype induced by  H. pylori  are highly needed.Aims   Our study was aimed at investigating the phenotype of  H. pylori -associated gastritis in two cohorts of monozygotic and dizygotic twins, using the OLGA/OLGIM gastritis staging system.Methods   Two cohorts of monozygotic (14 pairs) and dizygotic (15 pairs) dyspeptic twins prospectively underwent endoscopy with biopsy sampling based on Sydney protocol.  H. pylori  status and OLGA/OLGIM stages were assessed and compared.Results   The mean age of monozygotic and dizygotic twins was 40.4 and 38.6 years, respectively ( p  = 0.623). The overall prevalence of  H. pylori  infection was 51.7%. Among the 14 monozygotic twin pairs, five pairs were  H. pylori -positive, four were  H. pylori -negative, and five were  H. pylori -discordant. Among the 15 dizygotic twin pairs, five pairs were  H. pylori -positive, five were  H. pylori -negative, and five were  H. pylori -discordant. Concordance for antrum atrophy in monozygotic twins was 78.6% (11/14 pairs) and in dizygotic twins 73.3% (11/15 pairs) ( p  = 0.742). Concordance for corpus atrophy in monozygotic versus dizygotic twins was 92.9% (13/14 pairs) and 86.7% (13/15 pairs), respectively ( p  = 0.584). Concordance for antrum intestinal metaplasia (IM) in monozygotic twins was 85.7% (12/14 pairs) and in dizygotic 73.3% (11/15 pairs) ( p  = 0.411). Concordance for corpus IM in monozygotic twins was 85.7% (12/14 pairs) and in dizygotic 86.7% (13/15 pairs) ( p  = 0.941). Among monozygotic and dizygotic subjects, the stage of gastritis was concordant in both  H. pylori -positive and  H. pylori -negative subjects.Conclusions   In conclusion, histological gastric mucosa alterations in monozygotic and dizygotic twins showed high rates of concordance. Furthermore, OLGA/OLGIM gastritis stages were not modulated by the zygosity of the twins.

Gastritis Stages in Monozygotic and Dizygotic Dyspeptic Twins