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Campylobacter  spp. are zoonotic bacteria that cause gastroenteritis in humans and may cause extraintestinal infections such as Guillain-Barré syndrome, reactive arthritis, and bacteremia. Resistance to antibiotics is an increasing concern in the Sub-Saharan Africa; thus, search for alternatives such as plant-based active ingredients is important in order to develop new drugs.Objectives   To present a systematic review of  in vitro  and  in vivo  studies of the antibacterial activity of medicinal plants from Sub-Saharan Africa against  Campylobacter  spp.  Methodology . Studies published until March 2020 on medicinal plants used against  Campylobacter  spp. from each country of Sub-Saharan Africa were searched on PubMed, Science Direct, AJOL, and Google Scholar. Articles were selected based on the existence of information regarding  in vitro  and  in vivo  activity of medicinal plants against  Campylobacter  spp.Results   A total of 47 medicinal plants belonging to 28 families were studied for  in vitro  activity against  Campylobacter  spp. No plant was studied  in vivo.  Plants from Fabaceae family were the most commonly studied. The plants with the strongest antimicrobial activities were  Cryptolepis sanguinolenta  and  Terminalia macroptera . The root extracts from these plants were effective, and both had a minimal inhibitory concentration (MIC) of 25  μ g/ml. Seven pure compounds were isolated and analyzed for activity against  Campylobacter  spp. The compound cryptolepine from  C. sanguinolenta  was the most effective with MIC values ranging between 6.25 and 25  μ g/ml.Conclusion   Several native plants from the Sub-Saharan Africa region were studied for  in vitro  activity against  Campylobacter  spp. Some plants seemed very effective against the bacteria. Chemical compounds from three plants have been isolated and analyzed, but further studies are needed in order to produce new and effective drugs.

A Systematic Review of In Vitro Activity of Medicinal Plants from Sub-Saharan Africa against Campylobacter spp.