English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective   To investigate the influence of early bladder imaging (EBI) in experimental rabbits on the quantitative calculation of glomerular filtration rate (GFR) by the Gates method.Methods   We retrospectively analyzed the data of dynamic renal scintigraphy (DRS) in experimental rabbits. We calculated renal uptake during minutes 1-2 and 2-3 by correcting bladder radioactivity and computed the split GFR by renal uptake. Then, the EBI and GFR between 1-2 min and 2-3 min were compared, respectively.Results   The EBI proportion (57.3%) at 2-3 min of DRS was higher than that (8.5%) at 1-2 min ( P  < 0.05). The correlations between the 1-2 min and 2-3 min uptake rates of unobstructed kidneys after correction ( r  = 0.952‐0.979) were higher than those before correction ( r  = 0.859‐0.936). However, the correlation between the two in obstructed kidneys was not improved ( r  before  = 0.967 versus  r  after  = 0.968). For unobstructed kidneys, the difference in GFR based on 2-3 min uptake between before and after correction was significant ( P  < 0.05), but not in obstructed kidneys ( P  > 0.05). For GFR based on 1-2 min uptake, the difference between before and after correction was not significant in obstructed or unobstructed kidneys ( P  > 0.05). Before correction, the GFR of unobstructed kidneys of 10.5% of the rabbits in the protein load test was lower than that in the baseline status, but not so after correction.Conclusion   The 2-3 min EBI on DRS has a significant influence on the GFR calculated by the Gates method in experimental rabbits. Controlling water intake or calculating the GFR by 1-2 min renal uptake helps to avoid the influence of EBI on GFR.

Influence of Early Bladder Imaging in Experimental Rabbits on the Quantitative Determination of Glomerular Filtration Rate by the Gates Method