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Background   Previous researches indicate that  Itpr2  −/−  mice (inositol 1,4,5-trisphosphate receptor type 2 knockout mice) show depressive-like symptoms; however, little is known regarding the  in vivo  neurobiological effect of Itpr2 as well as the specific pattern of brain abnormalities in  Itpr2  −/−  mice.  Methods/Materials . First, behavioral tests, structural magnetic resonance imaging (MRI), and resting-state functional MRI were performed on  Itpr2  −/−  mice and matched healthy controls. Voxel-based morphometry and seed-based voxel-wise functional connectivity (FC) were, respectively, calculated to assess the gray matter volume and the functional activities of the brain in vivo. Second, the sample of relevant changed brain regions was extracted to detect the expression of BDNF. Finally, to further validate the relationship between Itpr2 deficiency and the observed brain abnormalities, we performed Western blotting to detect the expression of pro-BDNF and mBDNF in  Itpr2  −/−  C8-D1A (a type of astrocyte).Results   Compared with controls,  Itpr2  −/−  mice showed depressive-like behaviors as well as significantly lower gray matter volume in striatums mainly, periaqueductal GM, and the right frontoparietal cortices as well as lower striatal-hippocampal and striatal-right parietal cortex (mainly for the primary and secondary somatosensory cortex) FC. Moreover, decreased expression of mBDNF was found in both sample tissues of the striatum in  Itpr2  −/−  mice and  Itpr2  −/−  C8-D1A.Conclusion   By combining biochemistry and MR analyses, this study provides evidences to support that the Itpr2-related neuropathological effect is possibly mediated by the striatal abnormality associated with dysfunctional astrocytes in  Itpr2  −/−  mice  in vivo , thus may help us better understand underlying mechanisms of Itpr2 deficiency as well as its relation to depressive-like behavior.

neural plasticity

In Vivo Structural and Functional Abnormalities of the Striatums Is Related to Decreased Astrocytic BDNF in Itpr2-/- Mice Exhibiting Depressive-Like Behavior