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Objective   To evaluate the amount of  Fusobacterium nucleatum  ( F. nucleatum ) and  Prevotella intermedia  ( P. intermedia ) on subgingival recolonized plaque after mechanical debridement and photodynamic treatment by using blue light-emitting diodes (LEDs) in combination with topical  Curcuma longa  gel extract.Methods   A total of 12 subjects with stage III grade B periodontitis were recruited for the study. Maxillary posterior teeth with periodontal pocket >4 mm were selected. These teeth were examined for periodontal clinical data at baseline and at 1, 2, 4, and 6 weeks after treatment. All remaining teeth were treated by scaling and root planing (SRP). Then, the teeth were bilaterally divided using randomized split-mouth design with and without photodynamic adjunctive therapy (PDT). Samples of the subgingival microbiota were obtained in each visit. All samples were analyzed by multicolor TaqMan real-time polymerase chain reaction (PCR) for the presence of target bacteria.Results   Throughout the six-week follow-up, long-term improvement of probing depth and bleeding on probing was revealed on the PDT group. The number of subgingival  F. nucleatum  and  P. intermedia  also significantly reduced, compared to the baseline. There was a statistically significant recolonization in  F. nucleatum  and  P. intermedia  number after 2 and 4 weeks of conventional SRP, respectively. Our quantitative PCR method showed no significant recolonization of those subgingival bacteria on PDT sites throughout the 6-week study duration.Conclusion   The results showed that adjunctive photodynamic treatment by using blue LEDs in combination with topical  Curcuma longa  gel extract was effective to alter the recolonization patterns of  F. nucleatum  and  P. intermedia  after conventional debridement.

Anti-Early Stage of Bacterial Recolonization Effect of Curcuma longa Extract as Photodynamic Adjunctive Treatment