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Background   Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum. Leaf decoctions of  Cordia vignei  have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease.Aim   In this study, we investigated the effect of hydroethanolic extract of  Cordia vignei  have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease.Method   Male Sprague Dawley rats received oral treatment of either saline (10 ml/kg), sulfasalazine (500 mg/kg), or CVE (30-300 mg/kg) daily for 7 days. On day 4, colitis was induced by a single intrarectal administration of 500  μ l of acetic acid (4%  v / v /    Results   CVE significantly ( P  < 0.05) prevented colonic ulceration and reduced the inflammatory score. Serum levels of TNF- α  and IL-6 were significantly reduced. Depletion of superoxide dismutase (SOD) and catalase (CAT) activities by acetic acid was significantly inhibited while lipid peroxidation indexed as malondialdehyde (MDA) level in the colon was reduced. However, loss of body weight was not significantly affected by treatment with CVE.Conclusion   This data suggest that CVE has a potential antiulcerative effect.

international journal of chronic diseases

Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of<i>Cordia vignei</i>Leaves through Reduced Serum Levels of TNF-<i>α</i>and IL-6

Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract ofCordia vigneiLeaves through Reduced Serum Levels of TNF-αand IL-6