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Red ginseng is often combined with  Aconiti Lateralis Radix Praeparata  to reduce alkaloids-related toxicity of the latter. Such herb-pairing also results in better therapeutic effect in heart failure, as compared to the singular use of either herb. The purpose of this study was to investigate the effect of  Aconiti Lateralis Radix Praeparata  and its combination with red ginseng on the activities of CYP450 enzymes in rats. A sensitive and reliable HPLC-MS/MS method was established and validated for the simultaneous determination of eight probe drugs, phenacetin (CYP1A2), tolbutamide (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), dapsone (CYP3A4), 7-hydroxycoumarin (CYP2A6), bupropion (CYP2B6), and amodiaquine (CYP2C8), in rat plasma using diazepam as internal standard (IS). The chromatographic separation was performed on a Waters XBridge™ C18 column (2.1 mm × 100 mm, 3.5  μ m) using a gradient elution with the mobile phase consisting of acetonitrile and water (containing 0.1% formic acid) at a flow rate of 0.3 mL/min. The method was successfully applied in evaluating the effect of  Aconiti Lateralis Radix Praeparata  and red ginseng on the activities of CYP450 enzymes. The pharmacokinetic results of the eight probe drugs suggested that  Aconiti Lateralis Radix Praeparata  may inhibit the activity of CYP2A6, CYP2C19, CYP2B6, CYP1A2, CYP3A4, and CYP2C9 enzymes in rats. Comparison between the two groups,  Aconiti Lateralis Radix Praeparata  combined with red ginseng and  Aconiti Lateralis Radix Praeparata , indicated that red ginseng may inhibit the activity of CYP2D6 and CYP2B6 enzymes while inducing the activity of CYP1A2, CYP3A4, and CYP2C9 enzymes.

evidence-based complementary and alternative medicine

HPLC-MS/MS Analysis of <i>Aconiti Lateralis Radix Praeparata</i> and Its Combination with Red Ginseng Effect on Rat CYP450 Activities Using the Cocktail Approach

HPLC-MS/MS Analysis of Aconiti Lateralis Radix Praeparata and Its Combination with Red Ginseng Effect on Rat CYP450 Activities Using the Cocktail Approach