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Objective   This study was aimed to evaluate the antibacterial activity of the latex of three species members of  Jatropha  ( J. curcas ,  J. gossypilofia  Linn., and  J. multifida ) against  methicillin-resistant Staphylococcus aureus  (MRSA), extended-spectrum beta-lactamase- (ESBL-) producing  Escherichia coli  and ESBL-producing  Klebsiella pneumonia,  carbapenemase-resistant  Enterobacteriaceae  (CRE)- E. coli, K. pneumoniae -carbapenemase (KPC), and carbapenemase-resistant  Pseudomonas aeruginosa  (CRPA).Method   The antibacterial activities were calculated based on the inhibition zones using the Mueller–Hinton agar diffusion method, minimum inhibitory concentration (MIC) using Mueller–Hinton broth in a microdilution method, and minimum bactericidal concentration (MBC) using blood agar plate.Results   The latex of  Jatropha  showed antibacterial activities against the MRSA and CRPA. All latex of  Jatropha  appeared to have the antibacterial activities against MRSA and CRPA in the diffusion method (20.4–23.7 mm and 12–15 mm), MIC (0.19–6.25%, and 25%), and MBC (0.39–12.5% and 50%). Phytochemical screening of latex indicated the presence of flavonoids.Conclusions   The latex of  J. curcas ,  J.  g ossypilofia  Linn., and  J. multifida  has the potential to be developed as antibacterial agents, especially against MRSA and CRPA strain, but further in vivo research and discovery of the mode of its action are required to shed the light on the effects.

Antibacterial Potential of Jatropha sp. Latex against Multidrug-Resistant Bacteria