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Purpose   To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) function in eyes compromised by acute central serous chorioretinopathy (CSCR) after indocyanine green angiography-guided verteporfin (Visudyne®, Novartis Pharma, Basel, Switzerland) photodynamic therapy (PDT) with a half-fluence rate (25 J/cm 2 ).Methods   Quantitative data of SW-FAF grey values (SW-FAF GV) from a 350  μ m (SW-350) and 1200  μ m (SW-350) and 1200  t -test was calculated to explore the differences of SW-350 and SW-1200 between one month and the long-term follow-up.Results   Mean differences (95% CI) in SW-FAF GV between 1 month and 7 years after half-fluence PDT were 0.07 ± 0.11 for SW-350 ([95% CI: −0.002; 0.14],  p =0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21],  p =0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21],  p =0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21],  p =0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21],Conclusion   After 7 years, normalized SW-FAF GV were significantly lower in eyes with resolved acute CSCR treated with reduced-fluence PDT compared to the follow-up after 1 month without correlation to explicit pattern changes or structural damages. Half-fluence PDT remains a safe and considerable treatment option in acute CSCR.

Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy