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Acne is an inflammatory skin disorder; although some anti-inflammatory medicines for treating acne are available in a market, they have considerable side effects; therefore, new treatment options are needed. In the present study, among the 16 aqueous extracts of plants collected from Jeju Island in Korea which are used to test anti-inflammatory activity,  B. davidii  showed the strong decline of the proinflammatory cytokine expression against the inflammatory process caused by  C. acnes  in Human HaCaT keratinocyte cells.  B. davidii  downregulated the expression of 57% of COX-2, 41% of iNOS, and proinflammatory cytokines 29% of TNF- α , 32% of IL-1 β , 21% of IL-6, and 35% of IL-8. Furthermore,  B. davidii  inhibited NF- κ B and MAPK signaling cascades in keratinocytes that activated by toll-like receptor 2 (TLR-2) in response to  C. acnes . Given those results,  B. davidii  is a potential agent to reduce the proinflammatory cytokine expression against  C. acnes -induced inflammation and might provide an alternative to the current medications.

international journal of inflammation

Inhibition of Proinflammatory Cytokines in <i>Cutibacterium acnes</i>-Induced Inflammation in HaCaT Cells by Using <i>Buddleja davidii</i> Aqueous Extract

Inhibition of Proinflammatory Cytokines in Cutibacterium acnes-Induced Inflammation in HaCaT Cells by Using Buddleja davidii Aqueous Extract