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Bioactive constituents of numerous marine organisms have been investigated recently for their preclinical and clinical anticancer activity. Three marine organisms: black-spotted sea cucumber:  Pearsonothuria graeffei  ( Pg ), lollyfish:  Holothuria atra  ( Ha ), and sea hare:  Aplysia dactylomela  ( Ad ), were collected during winter 2019 from Gulf of Aqaba, Red Sea, Egypt, and macerated with ethanol into three different extracts:   Pg E ,   Ha E , and   Ad E , where each was  in vitro  assessed for its antiproliferative and proapoptotic properties on  HepG2 ,  HCT-116 , and  MCF-7  cancer cells.   Pg E  dose-dependently inhibited the growth of  HepG2 ,  HCT-116 , and  MCF-7  cells within IC 50  values 16.22, 13.34, and 18.09  μ g/mL, respectively, while the IC 50  values for the antiproliferative activity of   Ha E  were 12.48, 10.45, and 10.36  μ g/mL, respectively, and the IC 50  values of   Ad E  were 6.51, 5.33, and 6.87  μ g/mL, respectively. All extracts were found to induce G 0 /G 1  cell cycle arrest for  HepG2  cells side by side with their inhibition of  CDK2  on all three cell lines while all extracts were also showed to induce apoptosis in  HepG2  cell line at pre- G   1   phase supplemented by their anticancer activity via proapoptotic protein  Bax ,  caspase-3 , and cleavage  PARP  increase, and antiapoptotic protein  Bcl-2  downturn. Moreover, necrosis has been relatively noticed in  HepG2  cell line as an additional anticancer activity for each extract. Our data introduced three ethanolic marine extracts as natural chemotherapeutic agents to be further developed for cancer control.

Antiproliferative Activity, Proapoptotic Effect, and Cell Cycle Arrest in Human Cancer Cells of Some Marine Natural Product Extract