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Objective   There is no consensus on the role of abnormal uric acid (UA) levels in the prognosis of patients undergoing hemodialysis. We therefore aimed to investigate the effects of changes in UA concentration on the risk of all-cause death and cardiac death in such patients.Method   In this retrospective cohort study, patients admitted to two hemodialysis centers performing maintenance hemodialysis (MHD) in Wuhan First Hospital and Fourth Hospital Hemodialysis Center from January 1, 2007, to October 31, 2017, were included.Results   In all, 325 patients undergoing MHD aged 59.7 ± 14.7 years, including 195 men (60%), were enrolled, with a median follow-up of 37 months. Serum UA ( p  < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( p  < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( p  < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( p  < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( p  < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( p  < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( p  < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( p  < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (    Conclusion   Low UA levels were closely related to all-cause mortality in patients undergoing MHD. Although UA levels had no significant effect on cardiac death, they had a good predictive value for long-term prognosis in patients on MHD.

Association of Serum Uric Acid Concentration and Its Change with Cardiovascular Death and All-Cause Mortality