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Massa Medicata Fermentata  (MMF) is a traditional Chinese medicine (TCM) for treating indigestion and its related disorders. This study analyzes the effect of MMF on intestinal microorganisms in dyspepsia mice based on 16S rRNA technology. We take a dyspepsia model caused by a high-protein, high-calorie, high-fat diet. The 60 specific-pathogen free Kunming (SPF KM) mice were randomly divided into a model group ( n =12), an MMF group (LSQ group,  n =12), a Jianweixiaoshi group (JWXS group,  n =12), a domperidone group (DP group,  n =12), and a blank group ( n =12). On the seventh day of administration, mice were fasted and deprived of water. After 24 h, take the second feces of stress defecation in mice under strict aseptic conditions and quickly transfer them to a sterile cryotube. This study comprehensively evaluates the  α -diversity,  β -diversity, flora abundance and composition of each group of miceʼs intestinal microorganisms, and their correlation with functional dyspepsia based on the 16S rRNA gene sequencing technology. After modeling, some dyspepsia reactions, proximal gastric relaxation reduction, and intestinal microflora changes were noted. Dyspepsia mice showed dyspepsia reactions and proximal gastric relaxation reduction, characterized by a significant decrease of contents of gastrin ( P  < 0.01) and cholinesterase ( P  < 0.01). MMF can improve dyspepsia symptoms and promote proximal gastric relaxation. Significant intestinal flora disorders were found in dyspepsia mice, including downregulation of  Bacteroidetes ,  Lactobacillus,  and  Prevotellaceae  and upregulation of  Proteobacteria ,  Verrucomicrobia ,  Epsilonbacteraeota ,  Firmicutes ,  Lachnospiraceae NK4A136 group , and  Lachnospiraceae . MMF could alleviate intestinal microflora disturbance, and the regulation effect of MMF on  Bacteroidetes ,  Verrucomicrobia , and  Epsilonbacteraeota  was more reliable than that of Jianweixiaoshi tables and domperidone. The intestinal microflora may be correlated with the promoted digestion of MMF.

Effect of Massa Medicata Fermentata on the Gut Microbiota of Dyspepsia Mice Based on 16S rRNA Technique