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We report the case of a woman with a sporadic medullary thyroid carcinoma. Genomic analysis found that her tumor did not contain any common  RET  mutations but did harbor a  BRAF  V600E mutation. Only one other well-confirmed example of the BRAF V600E mutation has been reported in an MTC patient. We conclude that this common  BRAF  mutation may independently drive neoplastic transformation of human parafollicular C cells.

A BRAF V600E Mutation in RET-Negative Medullary Thyroid Cancer