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Seizure-related 6 homolog-like 2 ( SEZ6L2 ), which is localized on the cell surface, has been found to be associated with tumor angiogenesis and lung cancer progression. However, the role of  SEZ6L2  in hepatocellular carcinoma (HCC) is still unclear. We obtained data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) to investigate  SEZ6L2  expression and regulation in HCC. Then, HCC tissue samples were collected to verify  SEZ6L2  by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemical staining (IHC). Patient information was collected for survival and prognosis analysis. qRT-PCR, IHC, and bioinformatics analysis showed that the SEZ6L2 protein was highly expressed in HCC samples. Clinical data showed that high SEZ6L2 protein expression was correlated with tumor-node-metastasis (TNM) stages ( P  = 0.046), tumor number ( P  = 0.016), and tumor size ( P  = 0.029). Meanwhile, SEZ6L2 overexpression was closely associated with poor overall survival and disease-free survival in HCC patients. Moreover,  SEZ6L2  is an independent prognostic predictor for the survival of HCC patients. This study suggests a significant correlation between  SEZ6L2  and HCC, which means that  SEZ6L2  may potentially serve as a useful prognostic biomarker for HCC patients.

Upregulated Seizure-Related 6 Homolog-Like 2 Is a Prognostic Predictor of Hepatocellular Carcinoma