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Objective   To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response.Methods   Herein, 40 patients with IGM who had wounds requiring dressing change were enrolled and randomly divided into two groups: the CLY group and the control group. The size of the neoplasm and pain score of patients were followed-up for 4 weeks. Local tissues were taken during dressing change and examined by commercial enzyme-linked immunosorbent assay (ELISA) kits. The levels of inflammatory markers, including interleukin-1 β  (IL-1 β ), IL-2, IL-6, interferon gamma (IFN- γ ), and tumor necrosis factor- α  (TNF- α ) were measured.Results   After treatment, the size of the neoplasm in the CLY group was significantly smaller than that in the control group (14.28 cm ± 8.96 cm vs. 21.14 cm ± 0.12 cm,  P =0.038), and the pain scores were markedly reduced ( P =0.004). Besides, CLY downregulated the expression levels of IL-1 β , IFN- γ , and TNF- α .Conclusion   External use of CLY could reduce the neoplasm of IGM by inhibiting local inflammation. This trial is registered with  ChiCTR1800017744 .

evidence-based complementary and alternative medicine

Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial