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Numerous studies have shown that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of human cardiovascular diseases. However, whether lncRNA ezrin antisense RNA 1 ( EZR-AS1 ) is associated with the progression of coronary heart disease (CHD) remains unclear. Accordingly, the aim of the present study was to evaluate the role of lncRNA  EZR-AS1  in patients with CHD and in human venous endothelial cells (HUVECs). The findings revealed that lncRNA  EZR-AS1  was highly expressed in the peripheral blood of patients with CHD.  In vitro  experiments showed that the overexpression of  EZR-AS1  could enhance proliferation, migration, and apoptosis by upregulating the expression of EZR in HUVECs; downregulation of lncRNA  EZR-AS1  resulted in the opposite effect. lncRNA  EZR-AS1  was also found to regulate SET and MYND domain-containing protein 3 (SMYD3), a histone H3 lysine 4-specific methyltransferase, which subsequently mediated EZR transcription. Collectively, these results demonstrate that lncRNA  EZR-AS1  plays an important role in HUVECs function via SMYD3 signaling.

Long Noncoding RNA EZR-AS1 Regulates the Proliferation, Migration, and Apoptosis of Human Venous Endothelial Cells via SMYD3