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The consumption of a high-fat diet is linked to the development of obesity and considered a risk factor for cardiovascular diseases. The aim of this study was to evaluate the effect of the methanolic extract of  Moringa oleifera  leaves (MEML) on the high-fat diet- (HFD-) induced obesity and cardiac damage in rats. MEML, at a dose of 200 mg/kg/bw and 400 mg/kg/bw, was orally administrated to obese rats for 12 weeks.  M .  oleifera  leaves were proved to be rich in nutrients and minerals. Diversity of phenolic compounds in MEML was evidenced via LC-ESI-MS analysis. The chronic administration of HFD in rats led to an increase in the body weight gain, total cholesterol, and triglycerides and reduction in the HDL-C levels. The obtained results indicated a significant increase ( p  < 0.05) in the cardiac marker enzyme level in obese rats. A significant decrease ( p  < 0.05) in the levels of cardiac catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities was accompanied with an increase of malondialdehyde (MDA) level in the high-fat diet group when compared to those of the control. The treatment with the MEML alleviated abnormalities in the serum biochemical parameters, balanced the antioxidant status, and reestablished the normal histological structure of the heart especially in the case of the higher concentration.  Moringa oleifera  leaves may be a promising candidate in the management of obesity and its related complications such as heart problems.

Cardiac Ameliorative Effect ofMoringa oleiferaLeaf Extract in High-Fat Diet-Induced Obesity in Rat Model