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Objective   The aim of this study was to investigate the association between adiponectin gene polymorphisms  rs10937273 ,  rs1501299 ,  rs182052 ,  rs2241767 , and  rs266729  and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at providing approaches for the prevention and control of T2DM in combination with the characteristics of the local population.Methods   A case-control study was conducted including 406 Chinese participants, comprising 203 cases and 203 controls from various hospitals. Adiponectin ( ADIPOQ ) gene polymorphisms  rs10937273 ,  rs1501299 ,  rs182052 ,  rs2241767 , and  rs266729  were detected using an improved multiple ligation detection reaction technique. Generalized multifactor dimensionality reduction (GMDR) and logistic regression were conducted to analyze the associations between adiponectin gene polymorphisms and T2DM, as well as the interactions between adiponectin gene polymorphisms and environmental factors.Results    ADIPOQ  gene polymorphisms  rs10937273 ,  rs1501299 ,  rs182052 ,  rs2241767 , and  rs266729  were associated with type 2 diabetes. Based on the haplotype of the five adiponectin gene single-nucleotide polymorphism (SNP) loci, we found that G-G-A-A-C was a susceptible haplotype of T2DM ( P  < 0.05). Interaction analyses demonstrated associations between  rs1501299  and central obesity (consistency = 80%,  P  = 0.011) and between  rs266729  and  rs182052  and central obesity (consistency = 70%,  P  = 0.011).Conclusions   Our findings indicate that there is an interaction between the  ADIPOQ  gene and central obesity, which provides new insights into the prevention and treatment of T2DM.

Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot