English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background   The association studies of killer cell immunoglobulin-like receptors (KIRs) with the occurrence of myelodysplastic syndromes (MDS) are limited worldwide; this study investigated the genetic risk/protective factors of MDS in KIR and human leucocyte antigen (HLA) systems to gain a better understanding of the role played by KIR and their cognate HLA ligands in MDS pathogenesis.Methods   We genotyped a total number of 77 patients with MDS from Chinese Southern Han and 745 healthy controls for the  KIR  loci and  HLA class I . The carrier frequencies of  KIR  genes,  KIR  genotypes,  class I HLA  ligands, and  KIR-HLA  combinations were calculated by direct counting. The effect of individual  KIR  genes and  HLA  ligands on MDS risk was evaluated by logistic regression analyses using SAS 9.2 software.Results   We found that neither the  KIR  genes nor the  KIR  genotypes were associated with the occurrence of MDS. However, we observed that the frequencies for the strong inhibitory ligand  HLA-Bw4  as well as  KIR3DL1-HLA-Bw4  combination were significantly higher in healthy controls than those in the MDS patient group, respectively (73.42%  vs.  62.34%,  P  = 0.038; 70.87%  vs.  59.74%,  P  = 0.043).Conclusion   Our results showed that HLA-Bw4 ligand and KIR3DL1-HLA-Bw4 combination could confer a protective effect against MDS in Chinese Southern Han.

KIR3DL1 and HLA-Bw4 Interaction Showed a Favorable Role in Patients with Myelodysplastic Syndromes in Chinese Southern Han