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Background   Multidrug-resistant Enterobacteriaceae particularly extended-spectrum beta-lactamase producers have become a major public health threat. Despite efforts to limit their spread, rates of multidrug-resistance members of the Enterobacteriaceae continue to increase throughout the world causing increased morbidity and mortality and raised costs for medical care.Objective   The aim of this study was to determine the prevalence of multidrug resistance and extended-spectrum  β -lactamase-producing Enterobacteriaceae.Methods   Four hundred forty Enterobacteriaceae isolates from outpatients referred to Arsho Advanced Medical Laboratory were identified and assessed for their antimicrobial resistance pattern by using the automated VITEK 2 compact system. Extended-spectrum  β -lactamase production was determined by the VITEK 2 automated compact system using the extended-spectrum  β -lactamase test panel as per the instruction of the manufacturer.Results   The overall resistance rates of Enterobacteriaceae against cephalosporins, aminoglycosides, and fluoroquinolones were high. Nitrofurantoin with a resistance rate of 14.3% and piperacillin/tazobactam combination with a resistance rate of 17.3% were better active against this group of Gram-negative bacteria. Out of 440 isolates of Enterobacteriaceae, 42.1% were multidrug-resistant of which 34.3% and 8.95% were extensively drug-resistant and pan-drug resistant, respectively. Among 185 multidrug-resistant Enterobacteriaceae, 63.9% of the isolates produced extended-spectrum  β -lactamase of which 75.4%, 19.5%, 1.7%, 2.5%, and 0.8% were  E. coli ,  K. pneumoniae ,  C .  freundii ,  E .  cloacae , and  P .  mirabilis , respectively.Conclusions   The present study demonstrated high prevalence rates of multidrug-resistant and extended-spectrum-beta-lactamase-producing Enterobacteriaceae. In order to combat these problems, infection control strategy and proper antibiotic policies should be formulated.

journal of tropical medicine

High Prevalence of Multidrug-Resistant and Extended-Spectrum<i>β</i>-Lactamase-Producing Enterobacteriaceae: A Cross-Sectional Study at Arsho Advanced Medical Laboratory, Addis Ababa, Ethiopia

High Prevalence of Multidrug-Resistant and Extended-Spectrumβ-Lactamase-Producing Enterobacteriaceae: A Cross-Sectional Study at Arsho Advanced Medical Laboratory, Addis Ababa, Ethiopia