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Objective   To analyse the clinical features of diabetic peripheral neuropathy (DPN) and employ data mining technology to explore the rules of Chinese herbal medicine (CHM) therapy.Methods   The clinical data of 216 patients with DPN and qi-yin deficiency syndrome were obtained, and the clinical features of the patients were assessed by cluster analysis. Relevant information was entered into the clinical diagnosis and treatment collection system, and data mining techniques were used to analyse the drug frequency, core CHM, CHM pair, and so on.Results   In this study, glycated haemoglobin (HbA1c) and homocysteine (HCY) were closely related to the pathogenesis of DPN. Overall, 162 patients had typical DPN syndrome characteristics, and we analysed 216 prescriptions, including 182 CHM. The frequencies of prescription of  Astragalus membranaceus ,  Ligusticum wallichii ,  Poria cocos , and Radix Rehmanniae were greater than 45%. A Bayesian network analysis diagram showed that the 9 most common core CHM included  Astragalus membranaceus ,  Ligusticum wallichii ,  Poria cocos , atractylodes rhizome, and  Salvia miltiorrhiza  Bge. According to the association rules of CHM, Radix Ophiopogon is used for Codonopsis pilosula;  Astragalus membranaceus  and atractylodes rhizome for  Rehmannia  are also frequently used.  Astragalus membranaceus  and Cinnamomi Ramulus or  Ligusticum wallichii  and Moutan bark were highly related to a decreased Michigan Diabetic Neuropathy Score.Conclusion   HbA1c and HCY are related risk factors for DPN. Numbness is a typical syndrome characteristic.  Astragalus membranaceus  is a monarch CHM and is used most frequently.

Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients