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Purpose   To compare the corneal biomechanical properties between post-LASIK ectasia and primary keratoconus.Methods   A total of 42 eyes of 42 patients with matching age and central corneal thickness (CCT) were divided into two groups according to diagnosis of post-LASIK ectasia (PLE group;  n  = 21; age range: 22–47 years) and primary keratoconus (KC group;  n  = 21; age range: 21–47 years). The corneal biomechanical properties were assessed using Scheimpflug-based technology (Corvis ST; Oculus Optikgeräte, Wetzlar, Germany). The paired  t -test and linear regression analysis were performed.Results   The PLE group had significantly higher mean stiffness parameter at the first applanation (SP-A1; 76.65 ± 21.66 vs 52.72 ± 13.65,  p  ≤ 0.001) and mean stress-strain index (SSI) (SSI: 0.78 ± 0.16 versus 0.64 ± 0.12,  p =0.001) than the KC group. SP-A1 was positively correlated with CCT in the PLE group (Pearson's  r  = 0.816,  p  ≤ 0.001), but not in the KC group (Pearson's  r  = −0.014,  p =0.952). No statistical correlation was observed between SSI and CCT in either group (Pearson's  r  = 0.292,  p =0.199, and Pearson's  r  = 0.004,  p =0.985, respectively).Conclusions   In our case series, KC manifested more severe than PLE in biomechanical properties. Since SSI measurements were independent of corneal thickness, it can be used for corneal biomechanical assessment.

Comparison of Corneal Biomechanical Properties between Post-LASIK Ectasia and Primary Keratoconus