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Background   The spread of carbapenem-resistant  A. baumannii  (CrAb) is gaining worldwide attention. The spread of this pathogen is largely due to its ability to acquire various resistance genes of intrinsic and extrinsic origins that confer unpredictable susceptibility to  β -lactams. The aim of this study was to analyze  β -lactamase genetic compositions of CrAb in Malaysia.Methods   Whole-genome sequencing (WGS) was carried out on 13 CrAb isolates from clinical samples in Malaysia from 2011 to 2016.Results   Endotracheal aspirate was the dominant clinical sample source ( n  = 6), and only one isolate was obtained from wound swab. A total of 6 sequence types (STs) of the Oxford scheme were identified, including 4 reported STs and 2 novel STs. Eleven isolates were classified into clonal complex 92 (CC92/ICII), among which ST195 and ST208 were the most prevalent STs. All 13 CrAb isolates harbored multiple  β -lactamase genes.  bla  OXA-23  ( n  = 13) and  bla  OXA-66  ( n  = 11) were the dominant carbapenemase gene families found in these isolates. All isolates harbor  bla  ADC ,  bla  OXA-51-like , and  bla  OXA-23-like  genes.  bla  TEM  ( n  = 7),  bla  NDM-1  ( n  = 3),  bla  CARB-8  ( n  = 1), and  bla  PER-3  ( n  = 1) are amongst other  β -lactamase genes found in this study. IS Aba1  was found upstream to  bla  OXA-23  ( n  = 13),  bla  OXA-66  ( n  = 1), and  bla  ADC  ( n  = 11). All  bla  NDM-1  isolates had IS Aba125  (mobile genetic element) upstream to the genes. All isolates were positive for Tn 2006/2008  and Tn 2009  but were negative for Tn 2007 .Conclusion   Most of the isolates were grouped under the CC92 clonal complex which belongs to international clonal lineage 2. These findings predict that carriage of carbapenem-resistant genes possibly constitutes the underlying basis of high level of international clone II prevalence. Therefore, molecular surveillance and antimicrobial stewardship are essential in implementing policies to prevent and control the spread of CrAb in hospital settings.

the canadian journal of infectious diseases and medical microbiology/canadian journal of infectious diseases and medical microbiology

Detection of Antimicrobial Resistance Genes Associated with Carbapenem Resistance from the Whole-Genome Sequence of<i>Acinetobacter baumannii</i>Isolates from Malaysia

Detection of Antimicrobial Resistance Genes Associated with Carbapenem Resistance from the Whole-Genome Sequence ofAcinetobacter baumanniiIsolates from Malaysia