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Genetic studies have illustrated that  killer cell immunoglobulin-like receptor  ( KIR ) genes could participate in various autoimmune disorders. We aimed to clarify the role of  KIR  genes,  HLA  ligands, HLA-KIR interactions, and their genotypes in inflammatory bowel disease (IBD) susceptibility. The study population was composed of 183 IBD subjects, comprising 100 ulcerative colitis (UC) patients, 83 Crohn's disease (CD) patients, and 274 healthy subjects. Polymerase chain reaction with sequence-specific primers (PCR-SSP) was used to evaluate the absence or presence of the 15  KIR  genes, 5  HLA  class I ligands, and 2 pseudogenes. We did not find any significant difference in allele frequency of  KIRs  and pseudogenes between IBD patients and healthy controls. In the case of  HLA  genes, there was a significant difference in  HLA-B-Bw4 Thr80   frequency between UC patients and healthy controls ( P  = 0.03, OR = 0.06, 95%CI = 0.008-0.4). Furthermore, we found a significant difference in  HLA-C1 Asn80   frequency between CD patients and healthy controls ( P  = 0.04, OR = 0.49, 95% CI = 0.3-0.8). In the full-array combination of  KIR  genes, there was no significant frequency difference between UC patients and healthy controls, while two KIR genotypes showed a significant susceptible association with CD. Our data do not support a strong role of NK cells in IBD susceptibility, but it does not rule out a role for KIR variability in IBD patients. However, there are some protective associations such as Bw4 alleles; these associations may be due to the interaction of the alleles to TCRs rather than KIRs.

Analysis of Killer Cell Immunoglobulin-Like Receptor Genes and Their HLA Ligands in Inflammatory Bowel Diseases