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Aim   The BDNF dysfunction in the schizophrenia has been soundly documented. The  TrkB  gene is a high-affinity receptor of the BDNF that is changed in schizophrenia and mood disorders. The study had two aims: first, to identify whether the five nucleotide polymorphisms (SNPs) in  TrkB  gene are associated with a diagnosis of schizophrenia; and the latter, if any association exists between the  TrkB  SNPs and psychopathology, suicide attempts, and family history of schizophrenia in a Caucasian population.Methods   Case-control study (401 patients and 657 healthy controls) was used to examine a predisposition for schizophrenia. The tests for psychopathology, suicide attempts, and family history of schizophrenia were conducted only in patient group. The severity of the schizophrenia was measured using the five-factor model of the PANSS. In addition, the haplotype analysis for both the separate for SNPs of  TrkB  gene and in combination with the rs6265 SNP  BDNF  gene was conducted.Results   Our case-control study revealed that the genetic variants of rs10868235 (T/T polymorphic genotype) and rs1387923 (G/G polymorphic genotype) of the  TrkB  gene were associated with a higher risk of developing schizophrenia in men. However, the A/A wild genotype of rs1387923 was connected with a lower risk for both the development of and the family manifestation of schizophrenia in men. The G polymorphic allele of rs1565445 was associated with an increased risk of suicide in schizophrenia. The tested SNPs of the  TrkB  gene did not modulate the psychopathology of schizophrenia. The haplotype that was built with five SNPs in the  TrkB  gene was protective for men, but after joining the rs6265 SNP of the  BDNF  gene, a haplotype that was protective for women was created.

An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism